Medical & Healthcare

IRELEC designs and manufactures a range of automated systems for storing and withdrawing biological samples kept in nitrogen boxes.

Storage in nitrogen boxes is a tried and tested method for long-term storage of biological samples.

But when done manually, the operations to add and withdraw samples constitute a serious weakness of this storage method due to the risks they involve in terms of arduousness, safety of personnel and alteration of sample quality as a result of them getting warm.

Thanks to their architecture, the IRELEC automated systems protect personnel and preserve the cold chain for all samples during these operations, which are both critical and recurrent.

These automated systems are the only ones capable of adapting to existing biobank boxes.

Completely separable, they are modular and adapt to biobanks of all sizes.

These systems are very ergonomic and offer numerous possibilities (performance of important operations without personnel needing to be present, inventories, etc.).

The Grenoble CHU (University Hospital) biobank took delivery of an IRELEC automated cell in March 2017.

An expert in the measurement of the effects of chemical pollution on health and the environment, Tame-Water offers solutions that meet the needs of public stakeholders (authorities, unions, agencies, etc.) and private stakeholders (managers, companies, etc.).

The company develops measuring instruments at the cutting edge of innovation for autonomous performance, on site, of biotests for measuring the effects of pollution.

Tame-Water offers its clients an expert effluent analysis service. The company has also developed an offering produced with the INSITOX measuring machine, which enables any operator to measure toxicity in situ.

PMB designs, develops and manufactures the FlashKnife radiotherapy system which delivers an ultra-high dose rate in a fraction of a second, sparing healthy tissue while effectively destroying cancer cells. The efficacy of FLASH has been shown in several preclinical studies, reproducibly, as compared to the damage caused by conventional radiotherapy.

This very short irradiation time eliminates any effect of organ or tumour movement and greatly enhances the precision and accuracy of targeting.

PMB designs, develops and manufactures iMiGiNE, a robotised radioactive tracer production system.

iMiGINE is a combination of the ISOTRACE superconducting cyclotron and iMiLab, the innovative radiochemistry room, all assisted by a strict quality control system. Fully automated and robotised, iMiGiNE enables production by dose of a wide variety of injectable radiopharmaceuticals. A limited number of staff is needed for operation and its footprint is small.

This unique product changes the rules by enabling production of radiopharmaceuticals within imaging and research centres. iMiGiNE breaks away from the traditional centralised radioactive tracer production process, which is complicated and has limited results.

This system offers brand new possibilities in the fields of molecular imaging and nuclear medicine research. 

PMB designs and manufactures the iMiLab system, an integral part of the complete iMiGiNE system.

iMiLab is a radiochemistry room that produces various radioactive tracers based in particular on radio-isotopes ¹⁸F, ¹¹C and ⁶⁸Ga in a fully automated way. iMiLab is ultra-compact, self-shielded and complies with `Good Manufacturing Practices (GMP).

iMiLab utilises microfluidic techniques to produce various radioactive tracers in automatic synthesis boxes and in sterile cartridges, with on-board precursors and solvents. In particular, this system enables different radioactive tracers to be produced on the same day with no risk of cross-contamination.

PMB designs, develops and manufactures the iMiTRACE cyclotron, specifically designed for the in situ production of injectable radiopharmaceuticals for humans in PET (Positron Emission Tomography) imaging centres.

Its main characteristics are its compactness/lightness, acceleration of the protons to an energy of 12 MeV, self-shielding, a superconductive magnet and 4-port targetry.

The unique design of the iMiTRACE cyclotron guarantees great stability and availability in production. It is the result of the technological developments made to the OSCAR cyclotron (Oxford Instruments), with 20 years of proven reliability.

PMB designs, develops and manufactures a range of S band linear particle accelerators (LINAC ORIATRON), with energies 3, 4, 6 and 7 MeV.

The PMB teams also carry out maintenance of these machines guaranteeing quick service and maximum machine availability.

The LINAC ORIATRON has a focal spot reduced to 0.6 mm giving a higher dose rate. It has numerous possible options, helping it to meet the specific requirements of each project. 

ALCEDIAG develops EDITDIAG, personalised medicine solutions based on the analysis of blood samples in the field of mental health, specifically depression and suicidal tendencies.

EDITDIAG includes diagnosis, patient stratification and companion testing solutions.

The patented EDITDIAG technology is based on the analysis of a panel of epigenetic biomarkers in blood by next generation sequencing with results available in 48 hours. EDITDIAG provides medical teams with reliable, objective and quantitative data on the mental state of patients.

Thanks to EDITDIAG, ALCEDIAG supports medical teams through the diagnosis process, thus helping to improve patient well-being.

ALCEDIAG develops and sells EDITOX, a cellular test evaluating the risk for a molecule of causing secondary psychiatric effects in humans, in particular depression and suicide.

EDITOX is primarily intended for use by pharmaceutical companies during preclinical development phases to anticipate the potential secondary psychiatric effects in a drug candidate.

EDITOX is an effective, economically advantageous and ethical alternative to the tests currently conducted on rodents.

Sensitivity: 88% - Specificity: 99% (validated by a clinical study) 

SkillCell and Sys2Diag/CNRS have developed the EasyCOV saliva-based test dedicated to the fight against the Covid-19 pandemic.

Very easy to use, painless, highly reliable, requiring no interaction with a medical laboratory, EasyCOV delivers a result in 40 minutes through a visual interpretation of colour change. 

Designed and manufactured in France, EasyCOV is a Covid-19 screening solution that is efficient and economical.

SkillCell develops rapid and intelligent tests for health, food and environment. The company first products, currently under development, are:

• A urine test to screen for insulin resistance;
• A test to detect pesticides, in particular in food;
• A test to detect mosquitos’ eggs / larvae in watering places.

ITHPP has developed a packaging sterilization technology that can easily be integrated into production lines. 

Designed to integrate pharmaceutical, cosmetic and food industry processes, this innovative system uses pulsed electron beam technology and therefore does not require the use of chemicals. 

Its unique parameters provide access to high dosage rate, with a low energy consumption thus increasing the processing efficiency. This equipment significantly reduces production costs while increasing throughput.

PMB designs and manufactures a variety of HF components in-house: accelerating sections, electron guns, HF windows, ionisation chambers, filaments for guns, etc. 

TRONICO develops complex, high added value electronic dominance systems.

Drawing upon its 40 years of experience and ISO 13485 certification, TRONICO is able to satisfy the reliability and quality requirements of the medical sector. Alongside its core business of EMS (Electronic Manufacturing Services), TRONICO has established itself as an ODM (Original Design Manufacturer) in the development, specialising in medical devices (non-invasive systems, diagnostic instruments, invasive systems and implants).

TRONICO integrates into its clients' projects and provides support for risk management.

To be at the cutting edge of electronic component technology, TRONICO set up a component engineering laboratory to ensure the reliability of current designs and come up with the technological solutions of tomorrow.

TRONICO has developed a vast library of programmes and acquired considerable experience in the medical, energy, aeronautics, defence and security and transport fields.

The component engineering laboratory offers services such as:

• Entry control
• Construction analysis
• Component characterisation
• Life testing
• Obsolescence management
• Long-term storage